Salmon PDRN
Treatment in Seattle

Salmon PDRN therapy is a non-surgical treatment that helps hydrate the skin, reduce fine lines, and improve overall tone and texture, which is not FDA-approved. Initially developed for regenerative medicine, this therapy has since become widely used in aesthetic procedures. It supports collagen production, improves hydration, and can help restore smoother, healthier skin.

At Allure Esthetic, Dr. Javad Sajan offers Salmon PDRN therapy for patients seeking treatment for aging skin, acne scarring, and skin texture irregularities. This injectable, non-surgical treatment is tailored to your specific skin concerns with minimal downtime. It’s also backed by clinical research [1] and has gained mainstream attention after Kim Kardashian highlighted the benefits of salmon DNA-based therapy for restoring glow. ^[2]

Salmon PDRN is a specialized form of polydeoxyribonucleotide, a DNA-based molecule used in regenerative medicine to support skin repair and cell renewal. In non-surgical treatments, PDRN is extracted from wild salmon DNA, which shares compatibility with human skin.[3] This high similarity may help promote natural healing. ^[4]

At Allure Esthetic, we use a Salmon PDRN formulation known for its reported purity, possible clinical safety, and possible consistent skin-rejuvenating results. ^[5]

Salmon PDRN may work by activating your body’s natural repair systems, which may help your skin heal, rebuild, and rejuvenate. Its components may influence how certain skin and blood vessel cells respond during the natural healing process. Here's how this treatment works:

• Activates your skin’s repair system: It may help improve blood flow and support deep skin recovery. ^[6]
• Boosts Collagen-Producing Cells: Fibroblasts are skin cells that make collagen. PDRN may help activate a natural process in these cells that encourages them to grow and produce more collagen, especially types I and III, which keep skin firm and smooth. ^[7]
• Builds brand-new blood vessels: When PDRN is applied for healing, it has been shown to stimulate the formation of new micro-capillaries, the smallest blood vessels, and make tissue stronger overall. These new vessels are essential for bringing nutrients to areas of skin that have become damaged or aged by the sun. This may help speed up healing and restore skin vitality. ^[8]
• Reduces redness and inflammation: PDRN calms the skin by lowering irritation signals. This can help your skin feel less inflamed and recover faster after treatment. ^[9]
• Provides support for damaged cells: Salmon PDRN is made up of small DNA pieces. When injected, they act like repair parts that your cells can use to fix themselves, especially if the DNA in your skin has been damaged. It can also help your skin cells produce more energy and mitochondria, and protect collagen by reducing an enzyme called MMP-1, which normally breaks collagen down.^[10]

PDRN is a DNA-based ingredient often used in skincare treatments. It’s known for its potential to refresh the skin’s appearance. While it’s a popular choice in many cosmetic routines, individual responses can vary depending on skin type and overall condition.

While not FDA-approved, Salmon PDRN has been widely studied and used internationally for its regenerative and skin-rejuvenating effects:

• Supports collagen production: can help trigger a natural process in skin cells that boosts collagen production (types I and III). This can make the skin thicker, more elastic, and firmer, helping smooth out fine lines.^[11]
• Improves skin hydration and elasticity in sensitive areas: In a clinical study, polynucleotide gel injected around the eyes demonstrated improved hydration and elasticity over time compared to regular hyaluronic acid filler. ^[12]
• Speeds up healing and blood vessel growth: Studies show that using PDRN regularly can boost natural healing signals like VEGF and Angiopoietin-1. These may help the body grow tiny new blood vessels and make the skin stronger as it heals.^[13]
• Soothes Irritated Skin: PDRN has demonstrated anti-inflammatory activity and supports post-procedural recovery by minimizing redness, swelling, and irritation. ^[14]
• Lightens dark spots and uneven tone: Early clinical and laboratory evidence suggests that PDRN may reduce the activities of enzymes involved in melanin. This may contribute to the visible lightening of hyperpigmented skin.^[15]
• Improves raised and post-surgical scars: Preliminary case reports have observed improvements in scar pliability, elevation, and patient-reported comfort. These effects appear over time with repeated applications. ^[16]
• Protects skin from UV damage: PDRN may help your skin defend itself against sun-related damage by boosting antioxidant activity.^[17]

Here are the ideal candidates for Salmon PDRN therapy:

• Adults showing early-to-moderate photo-aging, such as fine lines, dull tone, or loss of elasticity. ^[18]
• Those who want to soften atrophic acne, surgical, or traumatic scars, without resorting to ablative surgery. ^[19]
• Patients planning for or recovering from energy-based resurfacing CO₂ laser, RF microneedling, or deep peels, who wish to shorten downtime. ^[20]
• Individuals troubled by patchy hyperpigmentation or post-inflammatory dark spots. ^[21]
• Individuals who want collagen-stimulating, anti-inflammatory injectables with a proven safety profile.^[22]
• Patients with slow-healing or ischemic wounds (e.g., diabetic foot ulcers) under physician oversight. ^[23]

Salmon PDRN therapy is not advised for the following people:

• Documented fish or shellfish hypersensitivity
• Pregnancy or breastfeeding
• Systemic immune dysregulation
• Coagulation disorders or current anticoagulant/antiplatelet therapy
• History of keloid or hypertrophic scarring in the treatment area
• Recent or ongoing oncologic disease
• Unrealistic expectations or untreated body-dysmorphic concerns

While generally well-tolerated, a detailed consultation, allergy screen, and informed consent process are essential. A thorough medical screening is required before starting treatment.

• Consultation & suitability check: Dr. Javad Sajan will review your medical history, recent procedures, active rashes or acne, and rule out contraindications such as pregnancy, autoimmune dermatoses, or uncontrolled diabetes. International medical guidelines emphasize that choosing the right patient is the most important step to ensure safe and effective treatment. ^[24]
• Local anesthesia & skin preparation: The face is double-cleansed with chlorhexidine or 70% alcohol, then a 4–7% lidocaine cream is occluded for 20 – 30 minutes to ensure comfort before the injections begin.
• Micro-papule injection technique: Using a 34–35G needle held at 10°, Dr. Sajan will deposit 0.02–0.05 mL blebs 0.5–1 cm apart within the superficial dermis. A flexible 25G cannula may be substituted in the mid-face or jawline zones for even product application.
• Session duration & immediate care: The injection phase takes about 15 minutes. After that, we apply a soothing cooling mask or LED light, then send you home with a zinc-based sunscreen. Any redness or tiny injection marks usually fade by the end of the day.
• Recommended treatment course: Most evidence-based protocols call for three sessions spaced 3–4 weeks apart, followed by a single maintenance booster at the 6- to 9-month mark.^[25]

Home after-care: You should avoid makeup, saunas, retinoids, and vigorous exercise for 24 hours, apply SPF 30+, and restart activities after 48 hours. Sleeping slightly elevated the first night helps minimize swelling. Mild bruising and tenderness are common and will self-resolve within 2–3 days.

The timeline outlines a commonly used three-session protocol designed for optimal skin regeneration and hydration. However, the number of sessions may vary based on individual skin goals and practitioner recommendations. While many patients choose the full three-session series for best results, some may benefit from fewer or additional treatments depending on their needs.

• Session 1 – Day 0: 0.2–0.3 mL micro-boluses placed intradermally across the target zone. Injection discomfort is brief; most patients experience pinpoint bleeding and a sunburn-like redness that fades within 24 hours. ^[26]
• Session 2 – Week 2: The same mild redness/bruising pattern is expected and generally resolves in 1–3 days. ^[27]
• Session 3 – Week 4: Final “build” injection for the first cycle. By now, objective tests show higher hydration and elasticity, and many people notice a dewier texture around weeks 4–5. ^[28]

Salmon PDRN treatment involves minimal downtime, with most visible effects resolving within 24 hours. Here’s what to expect during the healing process:

• First 6 hours: You’ll notice small bumps on the treated skin, which typically resemble small mosquito bites. They flatten within a few hours and don’t hurt. The skin may feel warm or slightly tight.
• 6 to 24 hours (Day 1): Mild redness and swelling are common. Some people may have light bruising, but it’s usually not noticeable unless you’re looking up close. These effects go down quickly.
• Day 2: Any small marks or bruises fade further. Most people feel comfortable returning to normal activities, including work and social events. Avoid intense exercise, hot showers, and saunas for now.
• Days 3–5: Skin generally looks clear by this time. You might experience a little dryness or itching as your skin starts to regenerate. Use a gentle moisturizer and sunscreen daily.
• After Day 5: No visible downtime remains. The product continues working under the skin to boost collagen and improve texture over the next few weeks.

Safety note: Multiple studies report no serious or delayed adverse events with PN/PDRN intradermal injections However this is a relatively newer treatment with limited studies. Limited data exists about benefits, side effects, adverse events, and complications. ^[29]

The cost of Salmon PDRN therapy depends on your individualized treatment plan, including the number of sessions needed and the method of delivery. At Allure Esthetic, each syringe of Salmon PDRN is priced at $900. Most patients use 1 to 2 syringes per session.

During your consultation, Dr. Javad Sajan will carefully evaluate your skin and discuss your goals to build a personalized plan. To make treatment more accessible, we offer flexible financing options and personalized payment plans. Our team will walk you through every option and help you choose what works best for your lifestyle and budget.

At Allure Esthetic, we focus on results you can trust. We use a Salmon PDRN formulation. The treatment is performed by Dr. Javad Sajan, a multi-award-winning plastic surgeon with years of experience in facial rejuvenation. He has been consistently rated among the top plastic surgeons in the world.

Take the next step toward radiant skin. Book your consultation online or call us at (206) 209-0988.

1. How long will my results last?

Most clinical studies show that injectable Salmon PDRN can help your skin build new collagen, which can visibly improve texture and firmness for about 6 to 12 months. Many patients opt for maintenance treatments every 9 to 12 months to preserve their results. ^[30] Also, individuals who use sunscreen and antioxidants daily often notice their glow lasting closer to the full year. ^[31]

2. Is Salmon PDRN safe for sensitive or Fitzpatrick IV-VI skin tones?

Yes, salmon PDRN can be safe for all skin tones, including Fitzpatrick types IV, V, and VI. It does not increase sun sensitivity or cause post-inflammatory hyperpigmentation. ^[32]

3. What does a typical appointment feel like?

Here’s what to expect during a typical appointment:

• Prep (10 minutes): We start by gently double-cleansing your skin, taking before photos, and applying a numbing cream to keep you comfortable.
• Injection (about 15 minutes): Small amounts of Salmon PDRN (0.2–0.3 mL each) are injected just under the skin about 1 cm apart using a tiny needle or soft-tipped cannula. Most people say it feels mild—just a slight sting, if anything.
• Aftercare (5 minutes): We’ll apply a soothing cooling mask or LED light treatment, then finish with a mineral-based sunscreen. Tiny red spots may appear but usually fade within 1–3 days.

Total Time: Around 30–40 minutes—quick enough to fit into your lunch break.

4. Can I combine with microneedling or laser resurfacing?

Absolutely. Microneedling immediately before PDRN micro-injections enhances trans-epidermal uptake, accelerating texture and scar refinement. Fractional lasers or RF-microneedling can likewise be paired, but allow 2 weeks between energy-based treatments and PDRN to minimize additive erythema.

5. How much does Salmon PDRN cost in Seattle?

The cost of Salmon PDRN treatment in Seattle can vary based on the provider’s expertise, clinic reputation, and your personalized treatment plan. At Allure Esthetic, each syringe is priced at $900.

6. What if I’m pregnant, breastfeeding, or actively on Accutane®?

If you’re pregnant or breastfeeding, it’s recommended to wait before starting the treatment. Since there’s no human safety data available, it's best to delay until after pregnancy and nursing. Also, if you’re currently taking isotretinoin (commonly known as Accutane®), you should hold off on treatment. Because this medication slows the skin’s ability to heal, most dermatologists advise waiting at least six months after your last dose before receiving any skin injections or microneedling.^[33]

1. 1,12,18 : Lee, Kar Wai Alvin, et al. “Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness.” International Journal of Molecular Sciences 25 (15), 2024: 8224.
2. Specter, Emma. “What, Exactly, Is the Kim Kardashian–Approved Salmon‑Sperm Facial, and Should I Be Saving Up for One?” Vogue, 13 June 2023.
3. Squadrito, Francesco, et al. “Pharmacological Activity and Clinical Use of Polydeoxyribonucleotide.” Molecules 22 (5), 2017: 748. 4,8,13 : Galeano, Mariarosaria, et al. “Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing.” Pharmaceuticals 14 (11), 2021: 1103.
4. 5,20,22,24,30 : Cavallini, Maurizio, et al. “Consensus Report on the Use of PN‑HPT™ (Polynucleotides Highly Purified Technology) in Aesthetic Medicine.” Journal of Cosmetic Dermatology 20 (3), 2021: 803‑815.
5. Minutoli, Letteria, et al. “Activation of Adenosine A2A Receptors by Polydeoxyribonucleotide Increases Vascular Endothelial Growth Factor and Protects Against Testicular Damage Induced by Experimental Varicocele in Rats.” Fertility and Sterility 95 (4), 2011: 1510‑1513.
6. 7,11,32 Shin, Sun Mee, et al. “Polydeoxyribonucleotide Exerts Opposing Effects on ERK Activity in Human Skin Keratinocytes and Fibroblasts.” Molecular Medicine Reports 28 (2), 2023: 148.
7. Galeano, Mariarosaria, et al. “Polydeoxyribonucleotide Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse.” Wound Repair and Regeneration 16 (2), 2008: 208‑216.
8. Baek, Ahreum, et al. “Polydeoxyribonucleotide Ameliorates IL‑1β‑Induced Impairment of Chondrogenic Differentiation in Human Bone‑Marrow‑Derived Mesenchymal Stem Cells.” Scientific Reports 14 (1), 2024: 26076.
9. Kim, Yeon‑Ji, et al. “Polydeoxyribonucleotide Activates Mitochondrial Biogenesis but Reduces MMP‑1 Activity and Melanin Biosynthesis in Cultured Skin Cells.” Applied Biochemistry and Biotechnology 191 (2), 2020: 488‑501.
10. Shin, Sun Mee, et al. “Polydeoxyribonucleotide Exerts Opposing Effects on ERK Activity in Human Skin Keratinocytes and Fibroblasts.” Molecular Medicine Reports 28 (2), 2023: 148.
11. Lee, Ye Jin, et al. “Comparison of the Effects of Polynucleotide and Hyaluronic‑Acid Fillers on Periocular Rejuvenation: A Randomized, Double‑Blind, Split‑Face Trial.” Journal of Dermatological Treatment 33 (1), 2022: 72‑78.
12. Galeano, Mariarosaria, et al. “Polydeoxyribonucleotide Stimulates Angiogenesis and Wound Healing in the Genetically Diabetic Mouse.” Wound Repair and Regeneration 16 (2), 2008: 208‑216.
13. Baek, Ahreum, et al. “Polydeoxyribonucleotide Ameliorates IL‑1β‑Induced Impairment of Chondrogenic Differentiation in Human Bone‑Marrow‑Derived Mesenchymal Stem Cells.” Scientific Reports 14 (1), 2024: 26076.
14. Noh, Tai Kyung, et al. “Novel Anti‑Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound‑Healing Booster.” International Journal of Molecular Sciences 17 (9), 2016: 1448.
15. Belmontesi, Magda. “Polydeoxyribonucleotide for the Improvement of a Hypertrophic Retracting Scar—An Interesting Case Report.” Journal of Cosmetic Dermatology 19 (11), 2020: 2831‑2835.
16. Kim, Hyoung Moon, et al. “A Mixture of Topical Polydeoxyribonucleotide, Vitamin C, and Niacinamide Attenuates Skin Pigmentation and Increases Elasticity by Modulating Nrf2.” Molecules 27 (4), 2022: 1276.
17. Lee, Kar Wai Alvin, et al. “Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness.” International Journal of Molecular Sciences 25 (15), 2024: 8224. Belmontesi, Magda. “Polydeoxyribonucleotide for the Improvement of a Hypertrophic Retracting Scar—An Interesting Case Report.” Journal of Cosmetic Dermatology 19 (11), 2020: 2831‑2835.
18. Cavallini, Maurizio, et al. “Consensus Report on the Use of PN‑HPT™ (Polynucleotides Highly Purified Technology) in Aesthetic Medicine.” Journal of Cosmetic Dermatology 20 (3), 2021: 803‑815.
19. Noh, Tai Kyung, et al. “Novel Anti‑Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound‑Healing Booster.” International Journal of Molecular Sciences 17 (9), 2016: 1448.
20. Cavallini, Maurizio, et al. “Consensus Report on the Use of PN‑HPT™ (Polynucleotides Highly Purified Technology) in Aesthetic Medicine.” Journal of Cosmetic Dermatology 20 (3), 2021: 803‑815.
21. Kim, Seoyoung, et al. “Polydeoxyribonucleotide Improves Peripheral Tissue Oxygenation and Accelerates Angiogenesis in Diabetic Foot Ulcers.” Archives of Plastic Surgery 44 (6), 2017: 512‑518.
22. Cavallini, Maurizio, et al. “Consensus Report on the Use of PN‑HPT™ (Polynucleotides Highly Purified Technology) in Aesthetic Medicine.” Journal of Cosmetic Dermatology 20 (3), 2021: 803‑815.
23. Park, Kui Young, et al. “Long‑Chain Polynucleotide Filler for Skin Rejuvenation: Efficacy and Complications in Five Patients.” Dermatologic Therapy 29 (1), 2016: 53‑56.
24. Park, Kui Young, et al. “Long‑Chain Polynucleotide Filler for Skin Rejuvenation: Efficacy and Complications in Five Patients.” Dermatologic Therapy 29 (1), 2016: 53‑56.
25. Park, Kui Young, et al. “Long‑Chain Polynucleotide Filler for Skin Rejuvenation: Efficacy and Complications in Five Patients.” Dermatologic Therapy 29 (1), 2016: 53‑56.
26. Lee, Ye Jin, et al. “Comparison of the Effects of Polynucleotide and Hyaluronic‑Acid Fillers on Periocular Rejuvenation: A Randomized, Double‑Blind, Split‑Face Trial.” Journal of Dermatological Treatment 33 (1), 2022: 72‑78. Kim, Man Soo, et al. “The Efficacy and Safety of Polydeoxyribonucleotide for Knee Osteoarthritis: A Systematic Review and Meta‑analysis of Randomized Controlled Trials.” Medicine 98 (39), 2019: e17386.
27. Cavallini, Maurizio, et al. “Consensus Report on the Use of PN‑HPT™ (Polynucleotides Highly Purified Technology) in Aesthetic Medicine.” Journal of Cosmetic Dermatology 20 (3), 2021: 803‑815.
28. Lee, Kar Wai Alvin, et al. “Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness.” International Journal of Molecular Sciences 25 (15), 2024: 8224.
29. Shin, Sun Mee, et al. “Polydeoxyribonucleotide Exerts Opposing Effects on ERK Activity in Human Skin Keratinocytes and Fibroblasts.” Molecular Medicine Reports 28 (2), 2023: 148.
30. Mysore, Venkataram, et al. “Standard Guidelines of Care: Performing Procedures in Patients on or Recently Administered Isotretinoin.” Journal of Cutaneous and Aesthetic Surgery 10 (4), 2017: 186‑194.